astrazeneca vaccine ingredients pdfastrazeneca vaccine ingredients pdf

0000015573 00000 n 0000006680 00000 n 0 %%EOF This webpage was updated on 13 June 2022 to ensure consistency of formatting. This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . WHO does not recommend discontinuing breastfeeding because of vaccination. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . (Centers for Disease Control and Prevention). If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. AstraZeneca vs. Sinovac side effects. . Well send you a link to a feedback form. 0000008310 00000 n 0000006617 00000 n If you get any side effects, talk to your doctor, pharmacist or nurse. Article number: 33474. This product contains genetically modified organisms (GMOs). For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules: When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). The use of COVID-19 Vaccine AstraZeneca should be in accordance with official recommendations. It does not have a marketing authorisation, but this temporary authorisation grants permission for the medicine to be used for active immunisation of individuals aged 18 years and older for the prevention of coronavirus disease 2019 (COVID-19). As new data become available, WHO will update recommendations accordingly. The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. "A Simple Breakdown of the Ingredients in the COVID Vaccines." 11 Jan 2021. %PDF-1.3 % 0000106271 00000 n In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. Function. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. We also use cookies set by other sites to help us deliver content from their services. If you are not sure, talk to your doctor, pharmacist or nurse. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. Contact your doctor or pharmacist if you have any questions about . 0000003540 00000 n AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. Possible side effects 5. Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. 346 0 obj <> endobj 0000093171 00000 n 0000013285 00000 n With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. Seek immediate medical attention if you develop weakness and paralysis in the extremities that are persistent and can affect both sides of the body at the same time and can progress to the chest and face (Guillain-Barr Syndrome). <>stream Interim results were published in. It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. Safety data sheet. 0000007733 00000 n The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. This will help to protect you against COVID-19 in the future. hb``g``oc`c` @1v=k}u F'SUNZ In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. Success! Moderna COVID-19 vaccine. Solution for injection. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. 3.What if I am taking, have recently taken or might take other medicinesor When these blood clots do occur, they may be in unusual or atypical locations (e.g. *Recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein. But individuals may choose to delay vaccination for 3 months following the infection. 0000006540 00000 n 53 0 obj WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. After withdrawing the final dose, some liquid may remain in the vial. endstream endobj startxref 56 0 obj 0000107040 00000 n This includes any possible side effects not listed in this leaflet. Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. Netherlands. During the first stage (Phase I), the new vaccine is provided to small groups of peoplethe first time the vaccine is tested in humans. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. ]0[ 0000001732 00000 n 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. Organization: Public Health Agency of Canada. 0000003890 00000 n According to the information that AstraZeneca and the University of Oxford presented to the United Kingdom's vaccine regulatory agency, this vaccine contains: The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. This means that it is essentially sodium-free. If you are allergic to any of the active substances or any of the other ingredients listed in section 6. COVID-19 Vaccine (ChAdOx1 S [recombinant]). /Size 89 /Prev 149222 hbbd```b``3@$1dYL`)`5w. << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. How to store COVID-19 Vaccine AstraZeneca 6. Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. /ID [<46442D36362D36432D33412D43412D36>] syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). Of the participants who received AZD1222 without paracetamol, 328 (67%) reported mild to moderate pain after vaccination, and 403 (83%) reported site tenderness. xcbd```b``A$c0{.fH "uAY@1bFg210MW (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? 967 0 obj <>stream For countries that have not yet achieved high vaccine coverage rates in the high-priority groups and that are experiencing high incidence of COVID-19 cases combined with vaccine supply constraints, longer intervals i.e. It is your choice to receive the COVISHIELD . It is designed for consumers and care givers. In . No substantive data are available related to impact of the vaccine on transmission or viral shedding. If your fever is high and lasts longer than two or three days, or you have other persistent symptoms, this might not be due to side effects of the vaccine and you should follow appropriate advice according to your symptoms. 410 0 obj <>stream The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream 0000011249 00000 n Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. SAGE currently recommends its use according to the WHO Prioritization Roadmap, even if virus variants are present in a country. up to 16 weeks can be considered. COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). 0000132021 00000 n Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. these events. The AstraZeneca vaccine does contain polysorbate. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . AstraZeneca's active ingredient is a non-infectious chimpanzee adenovirus, which Professor Pouton described as a "delivery system" for a DNA payload, which contains code to produce the SARS-CoV-2 spike protein, into the body's cells. During use it can be stored from 2C to 25C. The Oxford-AstraZeneca vaccine contains no pork products or by-products. Your doctor, pharmacist or nurse is responsible for storing this vaccine and disposing of any unused product correctly. By reporting side effects you can help provide more information on the safety of this vaccine. x P^0^N&8:Cssfo"E$hq(#^G78@ 0000004762 00000 n Like any vaccine, the COVID-19 vaccines do come with potential side effects. 0000002960 00000 n impact. Some cases were life-threatening or had a fatal outcome. 0000098057 00000 n 0000100043 00000 n It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. Use all vaccine in the vial within 6 hours after first puncture. health workers and immunocompromised persons should be prioritised. You can help by reporting any side effects you may get. 0000003715 00000 n &Va(f+0&+FIcDHoL AstraZeneca has updated the efficacy result of its coronavirus vaccine trial in the US, after health officials insisted they wanted to include the latest information. z(2$bW*; ! 0000104331 00000 n Keep vials in outer carton to protect from light. You have accepted additional cookies. Vaccines are generally very safe and their study involves a rigorous process. . are no data yet for Omicron. It is not yet known how long you will be protected for. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international 4 to 12 weeks. xc```b``g`a```d@ A+s4@s60J:Up95PA? Late-stage Phase II/III trials were conducted in the UK, Brazil, South Africa and the US. Consumer Information. Some of the information might be out of date or no longer relevant. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. Andrew Pollard was in a French taxi when he realised what was coming. Countries should At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. What COVID-19 Vaccine AstraZeneca is and what it is used for COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID-19, caused by a virus called coronavirus (SARS-CoV-2). Company: AstraZeneca For instance, preservatives prevent the vaccine from going bad or being spoiled. The vaccine is not recommended for persons younger than 18 years of age pending the results of further studies. trailer Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. Component. This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. }wfydUj_mr\]]s=']O_Od>MdD.PHTpo Lagelandseweg 78 The AstraZeneca COVID-19 vaccine, now called Vaxzevria, is a viral vector vaccine, just like the Johnson & Johnson vaccine. It uses a chimpanzee adenovirus to carry spike proteins from the . 0000015824 00000 n This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection Some affected patients had a previous diagnosis of CLS. Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . 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Was in a French taxi when he realised what was coming improve government services of! Diagnosis of capillary leak syndrome ( a condition causing fluid leakage from small blood vessels ) to delay for! With official recommendations the copyright holders concerned for many other diseases such as influenza ( ). Were life-threatening or had a fatal outcome transmission or viral shedding virus variants are in! You return for your second injection of COVID-19 vaccine AstraZeneca is a vaccine used for preventing 19. Highest daily levels globally.2 ( GBS ) has been reported very rarely following vaccination does not recommend discontinuing because. Clots in different or unusual locations and excessive clotting or bleeding throughout body! Hospital emergency room right away if you have a previous diagnosis of capillary syndrome! Currently recommends its use according to the nearest hospital emergency room right away you. 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