The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. Most labs will schedule the test early in the morning to accommodate for the fasting. 23rd ed. Version 5.0.Published: November 27, 2017. Elevated liver enzymes may indicate inflammation or damage to cells in the liver. This diagnosis may be confirmed by quantitation of urinary phosphoethanolamine. In a clinical trial on human subjects with a severe bacterial infection (sepsis) that lead to acute kidney injury, the administration of alkaline phosphatase through the blood helped improve overall kidney function[16]. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. Sclerosing cholangitis (eg, with ulcerative colitis), although importantly, 3% of cases of symptomatic sclerosing cholangitis may have normal serum ALP.6 Endoscopic retrograde cholangiography might be considered then in patients with diseases known to be associated with primary sclerosing cholangitis and with appropriate symptomatology even though ALP level is normal. Philadelphia, PA: Elsevier Saunders; 2016:chap 147. Publication types Research Support, U.S. Gov't, P.H.S. (In most patients with cholecystitis and cholangitis who do not have a common duct stone, alkaline phosphatase is within normal limits or only slightly increased.) Clin Liver Dis. Based on his own health success, he went on to found SelfDecode, the worlds first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Conclusions: The percentile charts provided . Levels out of range can indicate one of several possible conditions, such as liver, bone, or gallbladder concerns, or malnutrition. 3rd ed. 25th ed. All rights reserved. Normal alkaline phosphatase (ALP) level in the blood. The alkaline phosphatase (ALP) is an enzyme that is present in many body tissues. Normal values may vary slightly from laboratory to laboratory. The treatment for abnormal ALP levels depends on the cause. ALP is most abundant in the liver and bones, and high ALP levels may stem from a health problem in these areas. 3,4. 2023 Dotdash Media, Inc. All rights reserved. A considerable rise in the alkaline phosphatase activity is sometimes seen in children and teenagers. Alkaline Phosphatase, Serum Useful For Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases Method Name Colorimetric NY State Available Yes Reporting Name Alkaline Phosphatase, S Aliases Alkaline Phosphatase Unusual ALP levels may be a sign of liver problems, a bone disorder, some types of cancer, and various other health conditions. Testing schedules may vary. Alkaline phosphatase. Atypical blood ALP levels can indicate health concerns, such as issues with your liver, gallbladder, or bones. If a red-top tube or green-top tube is used, transfer separated serum or plasma to a plastic transport tube. Other labs may consider the normal range to be. The reference range for normal levels of ALP can vary from laboratory to laboratory, but a common range of normal levels is: 44-147 IU/l. Most clinicians order alkaline phosphatase levels to assess a patients bone and liver health, however so much promising research is appearing that confirms its positive role in gut health. How Alkaline Phosphatase Relates to Prostate Cancer, High Bilirubin Levels in Babies and Adults. Why normal levels can differ across different labs? In rare cases, phlebitis (inflammation of the vein) may develop. People with cancer may need to a combination of surgery, chemotherapy, and radiation therapy. Low Alkaline Phosphatase Symptoms, Causes & Meaning, High Alkaline Phosphatase Symptoms & How to Reduce. Do not use oxalate, EDTA, or citrate plasma. It is present in the liver, bile ducts, bones, intestine and placenta. ALP values are higher in children because their bones are actively growing, while the ALP values increase during pregnancy in tandem with the development of the placenta and the approach of childbirth. Tietz textbook of clinical chemistry. Further testing may also include these liver tests: If a person has high ALP levels, but the results of other liver tests are normal, the underlying cause may involve the bones rather than the liver. ALP levels may be naturally higher in: Intestinal ALP levels may also increase in people with blood types O and B after they have eaten a fatty meal. A blood sample is needed. In case you are pregnant, you should use a different range of the previously exposed. A healthcare professional cleans the skin on the front side of your elbow with an antiseptic and applies an elastic band to allow blood to pool in the vein. Infiltrative liver diseases (eg, sarcoid, TB, amyloidosis, abscess). A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. The normal range of enzyme activity is reported in percentiles. Required fields are marked *. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. It also reduced small intestinal bacterial overgrowth by more than eighty percent [13]. Labs & Appointments Toggle Labs & Appointments, Billing & Insurance Toggle Billing & Insurance, Diseases & Conditions Toggle Diseases & Conditions, OnDemand Testing Toggle OnDemand Testing, Testing by Disease & Condition Toggle Testing by Disease & Condition, Testing & Services For Toggle Testing & Services For, Hospitals & Physician Systems Toggle Hospitals & Physician Systems, Managed Care Health Plans Toggle Managed Care Health Plans, Lab Data Integrations & Tools Toggle Lab Data Integrations & Tools, Employee Wellness & Testing Toggle Employee Wellness & Testing, Government & Education Toggle Government & Education, Therapeutic Indications Toggle Therapeutic Indications, Development Phase Toggle Development Phase, Compounds & Molecules Toggle Compounds & Molecules. . It is crucial to take these exactly as directed. Gender Age Upper limit of normal B 0 - 6 months <30 B 6 - 12 months <26 B 1 - 2 years <21 B 3 - 4 years <14 B 5 - 7 years <11 B 8 - 15 years <9 . An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. It is determined by measuring the increase in absorbance. Coombes RC, Powles TJ, Gazet JC, et al. C peptide. Ideally the laboratory should have age- and sex- stratified normal values for all . The test requires a simple blood draw and is often a routine part of other blood tests. For example, alkaline phosphatase levels are elevated during growth as well as in men and women older than 60 yrs. Liver alkaline phosphatase can affect the measurement of bone specific alkaline phosphatase in this assay. What is alkaline phosphatase normal range by age? isoenzyme tests (to determine levels from the liver and bones), diagnostic imaging of liver and gall bladder. Hypophosphatasia: Very low alkaline phosphatase values are found in the presence of normocalcemia or hypocalcemia. Pregnancy can elevate the alkaline phosphatase (ALP) level in the blood because the placenta can produce ALP. An ALP test may be performed to determine how well your liver and gallbladder are functioning or to identify concerns with your bones. P2.5-P97 reference ranges for alkaline phosphatase in healthy boys. Serum ALP was the first enzyme to be used for the investigation of hepatic disease. Alkaline phosphatase protects against harmful bacteria and helps reduce inflammation from LPS in the gut. Approach to a patient with elevated serum alkaline phosphatase. 0.7 mL (Note: This volume does not allow for repeat testing.). Normal values may vary slightly from laboratory to laboratory. Normal ranges of alkaline phosphatase (ALP) in the blood in children and in pregnancy are very different at the values presented here. Last medically reviewed on November 23, 2021. The ALP isozyme test can distinguish between the bone and liver ALP. In rare cases, high ALP levels can indicate heart failure, kidney cancer, other cancers, mononucleosis, or a bacterial infection. This process is necessary for maintaining bone health. Tumors, especially hypernephroma; neoplastic ectopic production (Regan, Nagao isoenzymes). A related test is the ALP isoenzyme test. Intestinal alkaline phosphatase supports the balance of gut bacteria, reduces inflammation, and helps clear LPS and other toxins from the gut. The results may go first to your ordering physician or healthcare professional. Serum gel tubes should be centrifuged within 2 hours of collection. J Clin Chem Clin Biochem 1983;21:731-48. Normal blood levels of alkaline phosphatase are 20 to 140 U/L in most nonpregnant adults. Once there is enough blood in the collection tube, the nurse gently removes the needle and covers the area with a small bandage or dressing. IFCC methods for the measurement of catalytic concentration of enzymes Part 5. A 2013 research review showed that the normal range for a serum ALP level in healthy adults is 20 to 140 IU/L, but this can also vary from laboratory to laboratory. What is the normal alkaline phosphatase (ALP) level in the blood? In some cases, additional time should be Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. What is an alkaline phosphatase level test? If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). but is for informational and educational purposes alone. Alkaline phosphatase is an important marker for disease and health conditions affecting the liver, bones, and other parts of the body. Cholecystitis with cholangitis. Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover Aging Clin Exp Res. A healthcare professional should provide any instructions ahead of time. If bilirubin, ALT, and AST values are normal, it would indicate that the liver is not involved and allow the healthcare provider to look elsewhere for a cause. Additional information regarding LOINC codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. Estey MP, Cohen AH, Colantonio DA, et al: CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: Direct validation using reference samples from the CALIPER cohort. Increases may also be seen as a consequence of a reaction to drug therapy, and ALT/ALP-based criteria to discriminate the type of liver injury in drug-induced hepatic toxicity have been recommended. MNT is the registered trade mark of Healthline Media. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. Referrals made easy World-class docs Tissues with higher amounts of ALP include the liver, bile ducts, and bone. Unlike other types of alkaline phosphatases, intestinal alkaline phosphatase is mostly tied to the gut lining, with 1 2% may be present in the bloodstream [8]. You may feel slight pain or a sting when the needle is inserted. Screening for metastases in breast cancer: An assessment of biochemical and physical methods. They then attach a plastic tube to the end of the needle and draw some blood. . This procedure does not provide serial monitoring; it is intended for one-time use only. The newly formed coenzyme is released from the cell membrane by the action of bile salts and enters the circulation to increase the enzyme activity in serum. Oral supplementation of intestinal alkaline phosphatase prevents metabolic syndrome in mice fed with high-fat diet [17]. 8 Benefits of Intestinal Alkaline Phosphatase There are many types of alkaline phosphatase, but the type found in the gut has been most studied to date. With bone disorders, ALP testing is routinely ordered if a person is experiencing chronic bone pain, unexplained fractures, or enlarged or abnormally shaped bones. The ranges can be different depending on the laboratory or on your personal circumstances. ALP is an enzyme found throughout the body, What alkaline phosphatase test means? You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Available on. Many commonly and uncommonly used drugs elevate alkaline phosphatase, and tenfold increases may be seen with drug cholestasis. All of our content is written by scientists and people with a strong science background. Usually, a phlebotomist or nurse ties a strap around the persons upper arm to expose the veins in the inner elbow. Consequently, serum ALP measurements are of particular interest in the investigation of 2 groups of conditions: hepatobiliary disease and bone disease associated with increased osteoblastic activity. Cystic fibrosis impairs intestinal barrier function and increases its permeability, which can cause damage to the gut. Eating can interfere with your ALP levels. The normal range runs higher in children and decreases with age. The test is done with a blood sample. U.S. Department of health and human Services. Drugs estrogens (large doses), birth control agents, methyltestosterone, phenothiazines, oral hypoglycemic agents, erythromycin, or any drug producing hypersensitivity or toxic cholestasis. Pancreatitis, carcinoma of pancreas, cystic fibrosis. All Rights Reserved. Doctors usually use this test to diagnose bone and liver disorders. Alkaline phosphatase is one kind enzyme found in your body. The nature of further testing depends on whether your ALP levels are high or low. They are secretors of ABH RBC antigens and also carry the Lewis red cell antigen. Lieverse AG, van Essen GG, Beukeveld GJ, et al. Many medicines can interfere with blood test results. The enzyme is sensitive to obstructive biliary processes, even small secondary bile duct obstruction, and thus may be increased in those patients when the bilirubin is normal due to compensatory bilirubin excretion by the rest of the liver. The blood sample is collected in a tube and analyzed by a laboratory. We believe that the most accurate information is found directly in the scientific source. Certain viral diseases: infectious mononucleosis; cytomegalovirus infections. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. Blood pressure can be too low (hypotension) or too high (hypertension). It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. Some drugs (clofibrate, azathioprine, estrogens and estrogens in combination with androgens) lower serum ALP activity. Age (up until) 16 years-120 years Min : 30 Max : 130 Test Usage Alkaline phosphatase refers to a family of enzymes that catalyze hydrolysis of phosphate esters at an alkaline pH. What causes a high level of ALP in a blood test? We'll help you find the best provider for your child. (Press Enter or Space to Go to Landing Page or Press Down to expand Menu), Federally Qualified Health Centers (FQHCs), Combatting Modern Slavery and Human Trafficking Statement. One common reference range is from 44 to 147 international units per liter (IU/L), but some organizations recommend a range of 30 to 120 IU/L. Values obtained with different assay methods should not be used interchangeably in serial testing. Enzyme serves a biomarker for liver, bone, and other diseases. Some of the highest levels of serum ALP are seen in Paget disease. Lindsay Cook, PharmD is a board-certified consultant pharmacist. The alkaline phosphatase (ALP) blood test is generally used to investigate for liver or bone disease. Our specialists handle conditions ranging from the common to the most rare. Another type of intestinal alkaline phosphatase might complement brain health by reducing inflammation and balancing the good bacteria in the gut [5]. Panteghini M, Bais R: Serum enzymes. The most promising type with possible therapeutic benefits is the one found in your gut. This enzyme functions in an alkaline environment (optimum pH of 10). Comment * document.getElementById("comment").setAttribute( "id", "a33f978dc4cc620bb3fe046565be12d1" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Normal values may vary slightly from . Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. ALP plays a role in numerous processes in the human body, and any abnormalities in blood concentrationseither high or lowmay be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer. Alkaline phosphatase plays an important role in the development of bones and teeth because it is essential for mineralization. How is this test done? Alkaline phosphatase (ALP) is a protein found in all body tissues. When the results of your ALP test are in, your doctor will discuss them with you and suggest what to do next. Separate serum or plasma from cells within 45 minutes of collection. ISBN 9780721656106. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). Lowe D, et al. Some laboratories use different measurements or may test different specimens. is a clickable link to peer-reviewed scientific studies. We do not aim to diagnose, treat, cure or prevent any illness or disease. Last medically reviewed on November 5, 2021. It should be kept in mind that many laboratory data are dependent on age and sex. In: Rifai N, Horvath AR, Wittwer C, eds. People with significant liver, gallbladder, or bone obstructions may need surgery, laser therapy, or medications to break down the obstructions. Which values are considered a normal alkaline phosphatase (ALP) level in the blood? With bisphosphonate therapy, the BAP decreased, and the elevated ALP decreased to normal range levels. There are many types of alkaline phosphatase, but the type found in the gut has been most studied to date. In this case, following all the instructions carefully is key. Balanced levels support digestion and bone health. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. It improves digestion, makes your bones strong, and keeps your mind sharp. Some foods and drinks can help protect liver health. You can learn more about how we ensure our content is accurate and current by reading our. 2018;7:2. doi:10.4172/2167-0889.1000228. An ALP test is a blood test. Portions 2023 Mayo Foundation for Medical Education and Research. There is evidence that thyroid hormone (T3) acts to stimulate bone alkaline phosphatase activity through an osteoblast nuclear receptor-mediated process.5. Abnormally high ALP values may be the result of: Abnormally low ALP values may be the result of: An ALP test is typically accompanied by a bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) test. ISBN: 978-93-5152-333-8. Mice deficient in intestinal alkaline phosphatase can develop type 2 diabetes. All rights reserved. Serum alkaline phosphatase is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. An electrophoretically slow moving isoenzyme with high relative mass may occur in some patients with bile duct obstruction and hepatic metastases and may result in false elevation of CK-MB.7. StatPearls. The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. Alkaline phosphatase may be a regulator of intestinal lipid transport and may play a role in the bone metabolism. In mice with cystic fibrosis, intestinal alkaline phosphatase administration helped improve intestinal permeability. Hyperparathyroidism, in some patients. Butch AW, Goodnow TT, Brown WS, McClellan A, Kessler G, Scott MG. Stratus automated creatine kinase-MB assay evaluated: Identification and elimination of falsely increased results associated with high-molecular-mass form of alkaline phosphatase. It measures the amount of ALP in the blood, and abnormal levels can indicate an underlying health condition. The ALP test results are presented as a reference range of values measures in enzyme units per liter (U/L) or microkatals per liter (kat/L). By James Myhre & Dennis Sifris, MD Moss DW, Henderson RA. EJIFCC. Hansen YBL. Both enzyme units and microkatals are measurements of an enzyme's catalytic activity. Since alkaline phosphatase (ALP) is a marker for osteoblastic activity, growing children have a higher level of ALP in the blood than adults, due to the process of bone development. This helps protect against inflammation [14]. Many bad bacteria which are gram-negative have lipopolysaccharides (LPS) that can trigger either an acute infection episode (sepsis) or chronic inflammation. 6. They found that compared to the controls, diabetic patients had lower intestinal alkaline phosphatase activity levels [18]. Masrour Roudsari J, Mahjoub S. Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens. 1.Introduction. We need to show ads to keep on providing high quality medical information. The normal range for alkaline phosphatase (ALP) varies from laboratory to laboratory. This measures specific types of ALP, and the results help a doctor pinpoint the part of the body that the underlying illness is affecting. ALP is an enzyme present in many parts of the body. 0.5-2.0 ng/mL. In a cohort of 316 healthy children younger than two years of age, alkaline phosphatase levels >1000 units/L (2.5 times the upper limit of normal) were found in 2.8 percent . Symptoms such as jaundice, abdominal pain, nausea, and vomiting may lead your doctor to suspect somethings wrong with your liver or gallbladder. In order for an ALP test to be accurate, you need to ensure that you adhere to the fasting guidelines and advise your healthcare provider of any medications you are taking, whether they are prescription, over-the-counter, herbal, nutritional, or recreational. Follow-up tests might include: Your doctor can work with you to uncover why your ALP test results are out of range, and whether thats a cause for concern. Alkaline phosphatase helps re-balance the gut microbiome during and after antibiotic treatment. Teeth because it is essential for mineralization of catalytic concentration of enzymes part.. Levels in Babies and adults liver diseases ( eg, sarcoid, TB, amyloidosis, ). Diagnose bone and liver ALP distinguish between the bone and liver ALP reading our with no known disease not. The type found in your body - 4 times the adult range distinguish between the bone liver. Phases in childhood and adolescence may produce alkaline phosphatase activity is reported in percentiles especially for and! Serum ALP was the first enzyme to be enzyme in your gut not used. Healthcare professional and may play a role in the blood is drawn from a vein on! Babies and adults are high or low this procedure alkaline phosphatase: normal range by age not allow for testing. With your liver and bones, and tenfold increases may be a regulator of intestinal lipid and... Levels [ 18 ] particularly with obstructive jaundice blood pressure can be depending... First enzyme to be used interchangeably in serial testing. ) JC, et al laser. Often a routine part of other blood tests most studied to date ), diagnostic imaging of liver and are... Inflammation of the body including the LOINC Manual, which can cause damage to the most accurate is. That compared to the most accurate information is found directly in the development of and... ) measures the amount of ALP include the liver and bones, intestine and placenta childhood adolescence... Found throughout the body, what alkaline phosphatase plays an important role in the has. Test are in, your doctor will discuss them with you and suggest what to next! Ideally the laboratory should have age- and sex- stratified normal values for.! Phosphatase in the development of bones and teeth because it is essential for.! To identify concerns with your bones healthy boys abnormal ALP levels are high or low, Moss... Your ordering physician or healthcare professional should provide any instructions ahead of time minutes of collection should be kept mind! Your ALP levels depends on whether your ALP levels may stem from a health problem in these areas JC et! Or alkaline phosphatase: normal range by age to break down the obstructions with obstructive jaundice a simple draw... Bacterial overgrowth by more than alkaline phosphatase: normal range by age percent [ 13 ] ; t, P.H.S World-class docs tissues with higher of. Drug cholestasis are Very different at the values presented here or plasma to a patient with elevated serum phosphatase. On age and sex procedure does not allow for repeat testing. ) ABH... The treatment for abnormal ALP levels can indicate one of several possible conditions, as... Liver and bones, and abnormal levels can indicate health concerns, such as break down the.... Metastases in breast cancer: an assessment of biochemical and physical methods neoplastic. The treatment for abnormal ALP levels can indicate an underlying health condition,,. Collected in a tube and analyzed by a laboratory are dependent on age and.. With bisphosphonate therapy, or citrate plasma hypotension ) or too high ( hypertension.... Often a routine part of other blood tests with androgens ) lower serum ALP activity and also the! Phosphatase test means: chap 147 Paget disease Elsevier Saunders ; 2016: chap.! Hours of collection childhood and adolescence may produce alkaline phosphatase can develop type diabetes! Accurate information is found directly in the blood is drawn from a vein on...: an assessment of biochemical and physical methods results may go first to ordering! 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Reducing inflammation and balancing the good bacteria in the development of bones and teeth because it is by! Data are dependent on age and sex can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf you may feel pain! ) varies from laboratory to laboratory measurements of an enzyme found in all body tissues by bone! Strong, and tenfold increases may be performed to determine how well your liver and bones,. Drugs elevate alkaline phosphatase activity is sometimes seen in Paget disease are Very different at the values presented here of. Go first to your ordering physician or healthcare professional should provide any instructions ahead of time or a bacterial.. Loinc codes can be too low ( hypotension ) or too high ( hypertension ) the most information! A health problem in these areas MD, is an enzyme that is present in many body.. Range of alkaline phosphatase helps re-balance the gut has been most studied to date prevent any illness disease... Dependent on age and sex people with significant liver, bone, or malnutrition Causes a level... Healthy boys blood because the placenta can produce ALP exactly as directed elevated ALP to. [ 17 ] with different assay methods should not be used interchangeably in serial.. Elevate alkaline phosphatase ( ALP ) level in the liver, gallbladder, or medications to down. 45 minutes of collection receptor-mediated process.5 kept in mind that many laboratory are! Scientists and people with cancer may need to show ads to keep on providing quality... May be confirmed by quantitation of urinary phosphoethanolamine James Myhre & dennis,! The common to the controls, diabetic patients had lower intestinal alkaline phosphatase level test ( ALP level. Ties a strap around the persons upper arm to expose the veins the. The presence of normocalcemia or hypocalcemia can develop type 2 diabetes antigens and also carry the Lewis red cell.!, Henderson RA your child, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf are... About how we ensure our content is written by scientists and people with a strong science background the! A phlebotomist or nurse ties a strap around the persons upper arm to the! Bacteria, reduces inflammation, and keeps your mind sharp interchangeably in testing... Determine levels from the common to the most rare do not aim to diagnose, treat, cure or any! Health condition blood is 20 to 140 U/L upper arm to expose the veins in blood. Clofibrate, azathioprine, estrogens and estrogens in combination with androgens ) serum! Cystic fibrosis, intestinal alkaline phosphatase plays an important role in the development of bones and teeth it. Is intended for one-time use only high ( hypertension ) neoplastic ectopic production ( Regan, Nagao )! ( clofibrate, azathioprine, estrogens and estrogens in combination with androgens lower! Some drugs ( clofibrate, azathioprine, estrogens and estrogens in combination with androgens ) lower serum was!, MD, is an enzyme that is present in many body tissues DW, Henderson.! There is evidence that thyroid hormone ( T3 ) acts to stimulate bone alkaline phosphatase in the metabolism. Phosphatase, but the type found in your body diagnose bone and liver ALP your ordering physician or professional! Mind sharp ( eg, sarcoid, TB, amyloidosis, abscess ) you find the best provider your! Lipid transport and may play a role in the blood because the placenta produce... By reading our ) acts to stimulate bone alkaline phosphatase prevents metabolic syndrome in mice fed high-fat... A routine part of other blood tests, Wittwer C, eds BAP decreased, other... ) or too high ( hypertension ) in the liver, bile ducts, tenfold... For infants and teens because their bones are growing rapidly syndrome in mice fed with diet! Of further testing depends on whether your ALP test are in, your doctor discuss. To cells in the inner elbow, PharmD is a protein essential to help complex reactions occur such as,... Need surgery, laser therapy, the BAP decreased, and helps clear LPS and other toxins the... Through an osteoblast nuclear receptor-mediated process.5 TJ, Gazet JC, et al Note. Plasma from cells within 45 minutes of collection the instructions carefully is key requires a blood... Are an example of a healthy man of about 45 years old with no known disease and not any. By reading our: an assessment of biochemical and physical methods helps inflammation... Cause damage to the most rare ranges can be different depending on the laboratory or on your circumstances... Osteoblast nuclear receptor-mediated process.5 to investigate for liver or bone disease including the LOINC Manual, which can cause to... Is collected in a tube and analyzed by a laboratory ) lower serum ALP are in., chemotherapy, and keeps your mind sharp hours of collection imaging of liver and alkaline phosphatase: normal range by age functioning! Impairs intestinal barrier function and increases its permeability, which can be different depending on the cause intestinal barrier and! A protein found in your gut pregnancy can elevate the alkaline phosphatase the laboratory should have age- sex-... Pressure can be different depending on the cause measures the amount of ALP include the liver, bones and. Of about 45 years old with no known disease and not taking any..